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Screen Magnetic Selector Zhao Aixin

Abstract. A method to screen and isolate antigen specific clones from a library of single-chain antibodies expressed on the surface of yeast cells is presented. Two rounds of magnetic bead enrichment before flow cytometric sorting enables one to screen libraries of far greater diversity than can be screened by just flow cytometry. The strength of flow cytometric sorting is the ability to follow the selection in real

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  • Flow Cytometric Screening of Yeast Surface Display

    Abstract. A method to screen and isolate antigen specific clones from a library of single-chain antibodies expressed on the surface of yeast cells is presented. Two rounds of magnetic bead enrichment before flow cytometric sorting enables one to screen libraries of far greater diversity than can be screened by just flow cytometry. The strength of flow cytometric sorting is the ability to follow the selection in real

  • Genomewide synthetic lethal screen unveils novel CAIX

    Aug 27, 2021 The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival mechanisms governed by the tumor hypoxiainduced pH regulator carbonic anhydrase IX (CAIX). We identified a redox homeostasis network containing the iron-sulfur cluster enzyme, NFS1. Depletion of NFS1 or

  • Harvesting of Chlorella vulgaris using Fe3O4 coated with

    Jul 05, 2018 The Chlorella vulgaris harvesting was explored by magnetic separation using Fe3O4 particles coated with the plant polyphenol chemically modified by a Mannich reaction followed by quaternization (Fe3O4Q-PP). The N(R)4 and ClNC perssad of the Q-PP were linked to the Fe3O4 particles by NO bonds, as suggested by the X-ray photoelectron spectroscopy spectra. The

  • Whole Cell Screen for Inhibitors of pH Homeostasis in

    Jul 30, 2013 Bacterial pathogens like Mycobacterium tuberculosis (Mtb) encounter acidic microenvironments in the host and must maintain their acid-base homeostasis to survive. A genetic screen identified two Mtb strains that cannot control intrabacterial pH (pHIB) in an acidic environment infection with either strain led to severe attenuation in mice. To search for additional proteins that Mtb

  • A drug screen with approved compounds identifies

    Jun 05, 2021 Our results overlap with other studies performing similar Wnt/-catenin-based independent screening in cells (Figure S8), which reinforces the reproducibility of our findings (Biechele et al., 2010 Zhan et al., 2019 Zhao et al., 2012). Unique compounds identified in our screen are likely to be due to differences in the drug screen set-up ...

  • Magnetic networks of carbon quantum dots and Ag particles

    Mar 15, 2019 Furthermore, we anchored thiol-modified DNA on magnetic Ag self-assemblies through Ag S bonds to explore a magnetic selector to enriching sequence-specific DNA molecules under an applied magnetic field. Download Download high-res image (216KB) Download Download full-size image Scheme 1.

  • Magnetic Fishing Assay To Screen SmallMolecule

    Nov 10, 2010 Proteinprotein interactions are an intricate part of biological pathways and have become important targets for drug discovery. Here we present a two-stage magnetic bead assay to functionally screen small-molecule mixtures for modulators of protein-based interactions, with simultaneous affinity-based isolation of active compounds and identification by mass spectrometry. Proteins of interest ...

  • Magnetic Fishing Assay To Screen SmallMolecule Mixtures

    Nov 10, 2010 Proteinprotein interactions are an intricate part of biological pathways and have become important targets for drug discovery. Here we present a two-stage magnetic bead assay to functionally screen small-molecule mixtures for modulators of protein-based interactions, with simultaneous affinity-based isolation of active compounds and identification by mass spectrometry. Proteins of interest ...

  • Cytoplasm protein GFAP magnetic beads construction and

    Nov 18, 2020 It is very important to develop a highly efficient cerebrospinal fluid (CSF) detection system with diagnosis and prediction function, for which the detection of circulating tumor cells (CTCs) in CSF is a good choice. In contrast to the past use of epithelial EpCAM as CTCs separation target, a cytoplasm protein of GFAP antibody was first selected to construct highly-sensitive immunomagnetic ...

  • Magnetic Nanoparticle Composites Synergistic Effects

    The magnetic functionality is typically used for the magnetic separation of the MOFs from solution when used as catalysts, probes, or to locally heat via magnetic hyperthermia. A typical synthetic strategy for synthesizing an MOF-magnetic nanoparticle hybrid would be to grow the MOF in the presence of the NPs and have the magnetic nanoparticles ...

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